Why the study?
Do Na and K channel blockers affect the spatial and temporal dispersions of atrial refractoriness and terminate atrial fibrillation in a canine model?
Do Na and K channel blockers affect the spatial and temporal dispersions of atrial refractoriness and terminate atrial fibrillation in a canine model?
In a canine model of AF, the Na channel blocker pilsicainide terminated AF more effectively than the K channel blocker MS551 without increasing spatial dispersion of refractoriness.
Pilsicainide may terminate AF more effectively than MS551 without increasing spatial dispersion in canines; leaves open clinical translation.
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Shinagawa et al. (1998) studied this question.
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