Sodium channel blockers with slow recovery kinetics prolong atrial refractoriness greater during rapid excitation than potassium channel blockers in canine atrial fibrillation model.

Hideaki Kanki; Hideo Mitamura; Toshiaki Sato; Kaori Shinagawa; Seiji Takatsuki; Kouichiro Sueyoshi; Satoshi Ogawa

doi:10.5105/jse.18.315

January 1, 1998Japanese Journal of ElectrocardiologyOpen Access

Sodium channel blockers with slow recovery kinetics prolong atrial refractoriness greater during rapid excitation than potassium channel blockers in canine atrial fibrillation model.

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Why the study?

Does pilsicainide or MS-551 improve atrial fibrillation termination and electrophysiological parameters in a canine model of vagal nerve stimulation-induced atrial fibrillation?

Structured PICO

Does pilsicainide or MS-551 improve atrial fibrillation termination and electrophysiological parameters in a canine model of vagal nerve stimulation-induced atrial fibrillation?

P

Population

18 dogs in which atrial fibrillation lasting >15 minutes could be induced under vagal nerve stimulation

I

Intervention

Intravenous pilsicainide (sodium channel blocker) or MS-551 (potassium channel blocker) administered 5 minutes after atrial fibrillation induction

C

Comparator

Baseline (pre-drug) measurements

O

Outcome

Termination of atrial fibrillation and changes in electrophysiological parameters including monophasic action potential duration (MAPD), atrial effective refractory period (AERP), conduction velocity (CV), and atrial fibrillation cycle length (AFCL)surrogate

Sodium channel blockers like pilsicainide effectively terminate atrial fibrillation by increasing postrepolarization refractoriness during rapid excitation, unlike potassium channel blockers which show reverse use-dependent block.

Implication

Pilsicainide may outperform MS-551 for AF termination in this model; leaves open translation to human AF and requires clinical trials.

Discussion

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Cite This Study

Kanki et al. (1998) studied this question.

synapsesocial.com/papers/6a72b173a528af2d65c48111 https://doi.org/10.5105/jse.18.315

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Sodium channel blockers with slow recovery kinetics prolong atrial refractoriness greater during rapid excitation than potassium channel blockers in canine atrial fibrillation model.

Structured PICO

Implication

Discussion

Cite This Study

Sodium channel blockers with slow recovery kinetics prolong atrial refractoriness greater during rapid excitation than potassium channel blockers in canine atrial fibrillation model.

Structured PICO

Implication

Discussion

Cite This Study

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