Why the study?
Does a 5-day elevation of end-tidal PCO2 by 8 Torr alter ventilatory adaptation and chemoreflex sensitivities in healthy humans?
Population
10 healthy human subjects
Comparison
5-day exposure to a constant elevation in… vs Baseline measurements (before and after exposure)
Follow-up
13 days
Authors
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Hypothesis-generating for chemoreflex changes in sustained hypercapnia; leaves open relevance to clinical respiratory disorders.
Does a 5-day elevation of end-tidal PCO2 by 8 Torr alter ventilatory adaptation and chemoreflex sensitivities in healthy humans?
A 5-day constant elevation of end-tidal PCO2 increases ventilatory chemosensitivity to acute hypoxia but does not cause major ventilatory adaptation, challenging previous hypotheses regarding chronic hypercapnia.
Crosby et al. (2003) studied this question.
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