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Ischemic preconditioning in PCI remains uncertain; level 5 evidence leaves open the need for definitive trials.
Percutaneous coronary interventions are associated with myocyte damage. The repetitive brief periods of ischaemia protect the myocardium from a subsequent longer ischaemic insult and has been reported to reduce infarct size, preserve vascular endothelial function, decrease neutrophil accumulation and reduce apoptosis. However, this hypothesis remains debatable. The studies done so far have yielded heterogeneous results. 1
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Shrivastava et al. (2018) studied this question.
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