Key result
Remote ischaemic preconditioning reduces periprocedural MI ~42% during PCI, with greater lower limb benefit.
Why the study?
Does remote ischaemic preconditioning reduce periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention?
Population
731 patients undergoing percutaneous coronary intervention pooled from 5 RCTs. Median age 62, 25% female…
Comparison
Remote ischaemic preconditioning, performed… vs Control group.
Design
Meta-analysis
Authors
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Supports incorporation of remote ischaemic preconditioning into PCI protocols; extends evidence by identifying lower-limb superiority.
Meta-Analysis (n=731)
Does remote ischaemic preconditioning reduce periprocedural myocardial infarction in patients undergoing percutaneous coronary intervention?
Effect estimate: OR 0.58 (95% CI 0.36-0.93)
Remote ischaemic preconditioning significantly reduces the incidence of periprocedural myocardial infarction in patients undergoing PCI, with the greatest benefit seen when using the lower limb and in patients with multivessel disease.
D’Ascenzo et al. (2014) conducted a meta-analysis in Patients undergoing percutaneous coronary intervention (PCI) (n=731). Remote ischaemic preconditioning (RIPC) was evaluated on Periprocedural myocardial infarction (PMI) (troponin elevation >3 times upper reference limit) (OR 0.58, 95% CI 0.36-0.93). Remote ischaemic preconditioning significantly reduced periprocedural myocardial infarction in patients undergoing PCI (OR 0.58; 95% CI 0.36-0.93), with greater benefit using the lower limb.