Why the study?
Does targeted inhibition of calcineurin by MCIP1 attenuate the hypertrophic response and preserve ventricular function in mice subjected to pressure overload?
Population
Transgenic mice expressing a human cDNA encoding hMCIP1 in the myocardium and wild type littermates…
Comparison
Targeted inhibition of calcineurin via… vs Wild type littermates subjected to thoracic…
Design
Preclinical
Follow-up
3 weeks and 3 months
Authors
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Hypothesis-generating for calcineurin inhibition in pressure-overload hypertrophy; does not support clinical adoption without human trials.
Does targeted inhibition of calcineurin by MCIP1 attenuate the hypertrophic response and preserve ventricular function in mice subjected to pressure overload?
Targeted inhibition of calcineurin by MCIP1 attenuates pressure-overload cardiac hypertrophy while preserving ventricular systolic function in a mouse model.
Hill et al. (2002) studied this question.
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