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July 27, 2006Journal of Cardiovascular Electrophysiology

Interactions Between Paced Wavefronts and Monomorphic Ventricular Tachycardia: Implications for Antitachycardia Pacing

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Population

Six isolated rabbit hearts with endocardial cryoablation to limit viable tissue to visible epicardium and…

Comparison

Single and dual site pacing at 50%-90% of VT… vs Comparison between single and dual site pacing

Design

Preclinical

Authors

IBIsrael ByrdInspire Medical Systems (United States)MKMatthew W. KayGeorge Washington UniversityAPAndrew E. PollardUniversity of Alabama at Birmingham

Discussion

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Implication

Simultaneous dual-site capture may enable abrupt VT termination without proarrhythmia; hypothesis-generating for optimized ATP algorithms, requiring human validation.

Structured PICO

P
Population
Six isolated rabbit hearts with endocardial cryoablation to limit viable tissue to visible epicardium and establish apical tissue as the anatomic anchor
I
Intervention
Single (n=39) and dual (n=43) site pacing at 50%-90% of VT cycle length with eight pulses per trial
C
Comparator
Comparison between single and dual site pacing
O
Outcome
Termination of monomorphic ventricular tachycardia or induction of polymorphic ventricular tachycardiasurrogate

Effective separation of antidromic and orthodromic portions of the paced wavefront determines whether antitachycardia pacing abruptly terminates monomorphic VT or induces polymorphic VT.

Cite This Study

Byrd et al. (2006) studied this question.

synapsesocial.com/papers/6a72b6a93ce530166bc35ddbhttps://doi.org/10.1111/j.1540-8167.2006.00579.x

Topics

Ventricular arrhythmias
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