Influence of Postshock Epicardial Activation Patterns on Initiation of Ventricular Fibrillation by Upper Limit of Vulnerability Shocks
Why the study?
Do postshock epicardial activation patterns differ between episodes that initiate ventricular fibrillation versus those that do not following upper limit of vulnerability shocks?
Population
6 pigs with a 504-electrode sock pulled over the ventricles
Comparison
Ten S2 shocks of approximate ULV50 strength… vs Comparison between episodes that induced…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
First postshock cycle patterns identical regardless of VF induction; leaves open pre-cycle determination or probabilistic divergence thereafter in this animal model.
Structured PICO
Do postshock epicardial activation patterns differ between episodes that initiate ventricular fibrillation versus those that do not following upper limit of vulnerability shocks?
P
Population
6 pigs with a 504-electrode sock pulled over the ventricles
I
Intervention
Ten S2 shocks of approximate ULV50 strength delivered at the same S1-S2 coupling interval
C
Comparator
Comparison between episodes that induced ventricular fibrillation (VFI) and those that did not (NoVFI)
O
Outcome
Intercycle interval (ICI) and wave front conduction time (WCT) for the first 5 postshock cyclessurrogate
The first postshock cycle exhibits identical activation patterns regardless of whether ventricular fibrillation is induced, suggesting that shock outcome is either determined by undetectable initial electrophysiological differences or remains probabilistic until after the first cycle.
Cite This Study
Chattipakorn et al. (2000) studied this question.