Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 15, 1995Circulation

Comparison of Upper Limit of Vulnerability and Defibrillation Probability of Success Curves Using a Nonthoracotomy Lead System

View Full Paper
Ask AI
Bookmark
Share

Key result

The upper limit of vulnerability approximately equaled defibrillation at V97, though they differed by more than 100 V in 2 of 16 animals.

Why the study?

Does the upper limit of vulnerability (ULV) correlate with defibrillation (DF) probability of success curves in a nonthoracotomy lead system in a porcine model?

Population

16 pentobarbital-anesthetized pigs

Comparison

Upper limit of vulnerability testing and… vs Comparison between ULV and DF probability of…

Design

Preclinical

Authors

JSJoseph SouzaPikeville Medical CenterRMRobert MalkinDuke UniversityRIRaymond E. IdekerElectrophysiology

Discussion

Loading...

Member takes

Implication

May support ULV to estimate defibrillation needs in porcine models; leaves open clinical translation pending human validation.

Structured PICO

Does the upper limit of vulnerability (ULV) correlate with defibrillation (DF) probability of success curves in a nonthoracotomy lead system in a porcine model?

P
Population
16 pentobarbital-anesthetized pigs undergoing upper limit of vulnerability and defibrillation testing.
I
Intervention
Upper limit of vulnerability (ULV) testing (shocks delivered on the peak of the T wave) and defibrillation (DF) testing (shocks delivered after 10 seconds of fibrillation) using single-capacitor biphasic waveforms via a nonthoracotomy lead system
C
Comparator
Comparison between ULV and DF probability of success curves
O
Outcome
Correlation and difference between ULV and DF voltages (specifically at V97)surrogate

ULV approximately equals DF at V97, suggesting ULV could potentially estimate defibrillation requirements to reduce fibrillation inductions, though individual variability necessitates further algorithm refinement.

Limitations

  • Large difference between ULV V97 and DF in a few animals indicates that further improvement and testing of algorithms for determining ULV V97 must be developed before the technique is used clinically.
  • Large difference between ULV V97 and DF in a few animals indicates that further improvement and testing of algorithms for determining ULV V97 must be developed before clinical use

Cite This Study

Souza et al. (1995) studied Ventricular fibrillation (n=16). Upper limit of vulnerability (ULV) testing vs. Defibrillation (DF) testing was evaluated on Correlation between ULV and DF probability of success curves (V97). The upper limit of vulnerability approximately equaled defibrillation at V97, though they differed by more than 100 V in 2 of 16 animals.

synapsesocial.com/papers/6a9674dda43071aed1f6a254https://doi.org/10.1161/01.cir.91.4.1247
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relation between upper limit of vulnerability and defibrillation threshold in humans.1993 · 102 citations
  2. 2Effects of lidocaine on relation between defibrillation threshold and upper limit of vulnerability in open-chest dogs.1992 · 42 citations
  3. 3Electrophysiological Effects of Monophasic and Biphasic Stimuli in Normal and Infarcted Dogs1990 · 49 citations
  4. 4Stimulus-induced critical point. Mechanism for electrical initiation of reentry in normal canine myocardium.1989 · 388 citations
  5. 5A Method for Obtaining and Analyzing Sensitivity Data1948 · 1,217 citations