Why the study?
Do temporal profiles of emerging cardio-renal and pulmonary biomarkers predict adverse clinical outcomes in stable patients with chronic heart failure?
Population
263 stable patients with chronic heart failure (CHF)
Design
Cohort
Follow-up
2.2 years
Authors
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Serial biomarker profiles may refine CHF risk prediction; hypothesis-generating and requires prospective validation before clinical adoption.
Do temporal profiles of emerging cardio-renal and pulmonary biomarkers predict adverse clinical outcomes in stable patients with chronic heart failure?
Repeatedly measured levels of OPN, OPG, and HBP, and the slopes of OPG, TFF-3, and PSP-D trajectories strongly predict adverse clinical outcomes in patients with chronic heart failure, independent of NT-proBNP and troponin T.
Branković et al. (2018) studied this question.
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