Why the study?
Does blocking TFPI-α enhance fibrin formation under flow in blood from healthy subjects and hemophilia patients?
Population
Blood or plasma from healthy subjects, mice, and patients with haemophilia A or B
Comparison
Blocking of TFPI-α or genetic deficiency in TFPI vs Unblocked TFPI-α / wild-type
Design
Preclinical
Authors
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TFPI-α suppression of fibrin under flow should not yet alter practice; leaves open its restriction to low procoagulant conditions in vivo.
Does blocking TFPI-α enhance fibrin formation under flow in blood from healthy subjects and hemophilia patients?
TFPI-α antagonizes fibrin formation under flow in a manner dependent on and restricted by local TF/factor VIIa and factor Xa activities.
Thomassen et al. (2018) studied this question.
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