Why the study?
Does transdermal nicotine impair endothelial function in healthy individuals?
Population
21 healthy individuals (9 nonsmokers and 12 mild to moderate smokers)
Comparison
Transdermal nicotine (21 mg) patch for 4 hours vs Baseline (before nicotine patch)
Design
Other
Follow-up
4 hours
Authors
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May suggest endothelial impairment from nicotine in nonsmokers; hypothesis-generating and should not change practice.
Does transdermal nicotine impair endothelial function in healthy individuals?
Transdermal nicotine mimics smoking-induced endothelial dysfunction by reducing endothelium-dependent vasorelaxation in nonsmokers.
Maricene Sabha (2000) studied this question.
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