Why the study?
How do variations in dietary sodium intake affect cardiac design and pressure-volume characteristics in normotensive and hypertensive rats?
Population
Normotensive (WKY) and hypertensive (SHR) rats from 5 to 13-14 weeks of age
Comparison
Various dietary sodium treatments: 'low'… vs 'Control' sodium diet
Design
Preclinical
Follow-up
8-9 weeks (from 5 to 13-14 weeks of age)
Authors
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Preclinical rat data should not guide human sodium recommendations; leaves open load-independent mechanisms of cardiac remodeling in hypertension.
How do variations in dietary sodium intake affect cardiac design and pressure-volume characteristics in normotensive and hypertensive rats?
Variations in dietary sodium intake induce differentiated structural cardiac adaptations in normotensive and hypertensive rats that cannot be solely explained by pre- and afterload alterations.
Friberg et al. (1986) studied this question.
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