Why the study?
Does high dietary sodium increase left ventricular weight in normotensive rats?
Population
Three different normotensive rat strains, evaluated at young and mature ages
Comparison
High dietary sodium for 4 weeks vs Low dietary sodium (101 mumol Na+/g)
Design
Preclinical
Follow-up
4 weeks
Authors
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High sodium may promote LV remodeling independent of load in normotensive models; leaves open any human dietary implications pending clinical studies.
Does high dietary sodium increase left ventricular weight in normotensive rats?
High dietary sodium can induce left ventricular hypertrophy in specific strains of normotensive rats independent of cardiac volume or pressure overload.
Yuan et al. (1991) studied this question.
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