Why the study?
Does increased dietary sodium and ACE inhibition affect cardiovascular function differently in young versus aged normotensive rats?
Population
Young (3 months old) and aged (18 months old) male normotensive Wistar rats
Comparison
High-sodium diet with or without ACE inhibitor… vs Control diet (0.3% sodium in chow)
Design
Preclinical
Follow-up
6 weeks
Authors
Loading...
Caution against clinical extrapolation from rat data; hypothesis-generating for age-specific sodium-ACEi effects in humans.
Does increased dietary sodium and ACE inhibition affect cardiovascular function differently in young versus aged normotensive rats?
Increased dietary sodium produces age-dependent cardiovascular changes in normotensive rats, increasing blood pressure in aged rats and renal mass in young rats, while attenuating the benefits of ACE inhibition.
Teräväinen et al. (1997) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: