Why the study?
Does a long-term high-salt diet induce cardiac hypertrophy through volume overload and arterial stiffness in Sprague-Dawley rats?
Population
Sprague-Dawley rats from weaning to 5 months of age
Comparison
High-salt diet with or without bosentan vs Regular diet (NS)
Design
Preclinical
Follow-up
From weaning to 5 months of age
Authors
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High-salt effects on rat cardiac structure via volume overload warrant caution in dietary extrapolation; leaves open endothelin-independent mechanisms and human translation.
Does a long-term high-salt diet induce cardiac hypertrophy through volume overload and arterial stiffness in Sprague-Dawley rats?
Long-term high sodium intake in rats induces concentric cardiac hypertrophy driven by increased plasma volume and slight blood pressure elevation, rather than arterial stiffness or endothelin pathways.
Cordaillat et al. (2011) studied this question.
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