Key result
A chronic high sodium intake in normotensive male Wistar rats resulted in an attenuation of vascular sympathetic function, including attenuated blood pressure responses to spinal sympathetic outflow.
Why the study?
Does a high sodium diet alter sympathetic nervous function in normotensive male Wistar rats?
Population
Normotensive male Wistar rats
Comparison
High sodium chow (1400 mEq/kg) for 4 weeks vs Standard sodium chow (141 mEq/kg) for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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High-salt effects on sympathetic function in normotensive rats; hypothesis-generating and should not inform human dietary guidelines.
Does a high sodium diet alter sympathetic nervous function in normotensive male Wistar rats?
A chronic high sodium intake in normotensive rats attenuates vascular sympathetic function without altering basal blood pressure.
Bush et al. (1983) studied Normotensive. High sodium diet vs. Standard sodium diet (141 mEq/kg) was evaluated on Sympathetic nervous function (blood pressure and heart rate responses). A chronic high sodium intake in normotensive male Wistar rats resulted in an attenuation of vascular sympathetic function, including attenuated blood pressure responses to spinal sympathetic outflow.
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