PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
September 1, 1993Hypertension15 citationsOpen Access

Excitatory sympathetic reflex in NaCl-sensitive spontaneously hypertensive rats.

View Full Paper

Why the study?

Does a high (8%) NaCl diet alter the lumbar sympathetic nerve activity response to acute volume expansion in NaCl-sensitive spontaneously hypertensive rats?

Population

Male NaCl-sensitive spontaneously hypertensive rats, NaCl-resistant spontaneously hypertensive rats…

Comparison

High NaCl diet for 3 weeks followed by acute… vs Basal NaCl diet for 3 weeks followed by acute…

Design

Preclinical

Follow-up

3 weeks

Authors

YNYoshio NakamuraDCDavid A. CalhounYCY F Chen

Discussion

Loading...

Member takes

Overview

Supports vagal mediation of sympathetic hyperactivity in experimental salt-sensitive hypertension; leaves open human relevance.

Structured PICO

Does a high (8%) NaCl diet alter the lumbar sympathetic nerve activity response to acute volume expansion in NaCl-sensitive spontaneously hypertensive rats?

P
Population
Male NaCl-sensitive spontaneously hypertensive rats, NaCl-resistant spontaneously hypertensive rats, Wistar-Kyoto rats, and Sprague-Dawley rats at 10 weeks of age
I
Intervention
High (8%) NaCl diet for 3 weeks followed by acute volume expansion with whole blood
C
Comparator
Basal (1%) NaCl diet for 3 weeks followed by acute volume expansion with whole blood
O
Outcome
Lumbar sympathetic nerve activity response to acute volume expansionsurrogate
Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Nakamura et al. (1993) studied this question.

synapsesocial.com/papers/6a20dac76fcc58ca6c17fe03https://doi.org/10.1161/01.hyp.22.3.285
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High-NaCl diet reduces cardiac vagal afferent nerve response to volume expansion1987 · 6 citations
  2. 2Dietary Salt Intake Exaggerates Sympathetic Reflexes and Increases Blood Pressure Variability in Normotensive Rats2014 · 94 citations
  3. 3Cardiac volume receptor reflex in borderline hypertensive rats.1993 · 13 citations
  4. 4Cardiopulmonary Baroreflex in NaCl-Induced Hypertension in Borderline Hypertensive Rats1997 · 10 citations
  5. 5Alterations in sympathetic nerve traffic during cigarette-smoking in man1991 · 2 citations