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April 1, 1987AJP Regulatory Integrative and Comparative Physiology

The increase in cardiac vagal afferent nerve activity during volume expansion was less in rats consuming high compared with normal dietary NaCl intake, whereas efferent renal sympathetic nerve activity decreases during central vagus nerve stimulation were similar.

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Why the study?

Does high dietary NaCl intake reduce cardiac vagal afferent nerve response to volume expansion in anesthetized rats?

Population

Anesthetized normal rats prepared for separate examination of the afferent and efferent limbs of the…

Comparison

High dietary NaCl intake vs Normal dietary NaCl intake

Design

Preclinical

Authors

GDGerald F. DiBonaLSLinda L. Sawin

Discussion

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Overview

High salt may blunt rat cardiopulmonary baroreflex gain at the afferent limb; leaves open relevance to human salt-sensitive hypertension.

Structured PICO

Does high dietary NaCl intake reduce cardiac vagal afferent nerve response to volume expansion in anesthetized rats?

P
Population
Anesthetized normal rats prepared for separate examination of the afferent and efferent limbs of the cardiopulmonary baroreceptor reflex (sinoaortic-denervated rats)
I
Intervention
High dietary NaCl intake
C
Comparator
Normal dietary NaCl intake
O
Outcome
Cardiac vagal afferent nerve activity during intravenous volume expansion and efferent renal sympathetic nerve activity during electrical stimulation of the central vagus nervesurrogate

High dietary NaCl intake decreases overall cardiopulmonary baroreceptor reflex gain during intravenous volume expansion by acting on the afferent limb of the reflex arc.

Cite This Study

DiBona et al. (1987) studied this question.

synapsesocial.com/papers/6a951278b1a163ea01768c32https://doi.org/10.1152/ajpregu.1987.252.4.r687
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