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December 1, 1991Journal of Hypertension

Alterations in sympathetic nerve traffic during cigarette-smoking in man

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Why the study?

Does administration of atrial natriuretic peptide decrease blood pressure and sympathetic nerve activity in spontaneously hypertensive rats?

Population

Conscious, freely moving NaCl-sensitive spontaneously hypertensive rats, NaCl-resistant SHR, and…

Comparison

Intravenous and intracerebroventricular… vs SHR-R and WKY rats, and basal vs high-NaCl diets

Design

Preclinical

Authors

GGGuıdo GrassıGSGino SeravalleDCDavid A. Calhoun

Discussion

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Overview

ANP sympatholysis in salt-sensitive hypertensive rat models; leaves open translation to human hypertension therapy.

Structured PICO

Does administration of atrial natriuretic peptide decrease blood pressure and sympathetic nerve activity in spontaneously hypertensive rats?

P
Population
Conscious, freely moving NaCl-sensitive spontaneously hypertensive rats (SHR-S), NaCl-resistant SHR (SHR-R), and Wistar-Kyoto (WKY) rats with intact baroreflexes, maintained on basal and high-NaCl diets for 2-3 weeks.
I
Intervention
Intravenous and intracerebroventricular administration of atrial natriuretic peptide (ANP)
C
Comparator
SHR-R and WKY rats (control strains), and basal vs high-NaCl diets
O
Outcome
Blood pressure and lumbar sympathetic nerve activity (LSNA)surrogate

Circulating ANP exerts a sympatholytic effect in NaCl-sensitive spontaneously hypertensive rats that is partially mediated centrally but not amplified by high-NaCl feeding.

Cite This Study

Grassı et al. (1991) studied this question.

synapsesocial.com/papers/6a7eb4eb769bdd359bcda003https://doi.org/10.1097/00004872-199112000-00010
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