Why the study?
Does a high sodium diet alter adrenergic mechanisms and cardiovascular reactivity in rats and mice?
Population
Sprague-Dawley rats and NMRI mice
Comparison
High sodium (8%) diet for 4 weeks vs Normal sodium (0.3%) diet for 4 weeks
Design
Preclinical
Follow-up
4 weeks
Authors
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High-salt diets may heighten stress-induced cardiovascular reactivity via sympathetic tone in rodents; leaves open human relevance and mechanisms.
Does a high sodium diet alter adrenergic mechanisms and cardiovascular reactivity in rats and mice?
Chronic salt loading in rats increases sympathetic tone and cardiovascular reactivity to stress without altering central noradrenaline turnover or alpha-adrenoceptor responsiveness.
Gradin et al. (1987) studied this question.
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