Why the study?
Does high dietary sodium intake induce cardiac remodeling in spontaneously hypertensive rats compared to Wistar-Kyoto rats?
Population
Young spontaneously hypertensive rats (sodium-sensitive) and Wistar-Kyoto rats (sodium-resistant)
Comparison
High sodium intake for 2-12 weeks vs Control diet
Design
Preclinical, randomly allocated
Follow-up
2-12 weeks
Authors
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High sodium may promote concentric remodeling independent of sustained hypertrophy or BP rise; hypothesis-generating for human dietary sodium effects.
Does high dietary sodium intake induce cardiac remodeling in spontaneously hypertensive rats compared to Wistar-Kyoto rats?
High dietary sodium induces early transient hypertrophy followed by concentric remodeling in normotensive rats, whereas in hypertensive rats, remodeling occurs without initial hypertrophy at moderate sodium levels.
Leenen et al. (1998) studied this question.
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