Why the study?
Does a high sodium diet increase blood pressure and cardiac hypertrophy in Wistar rats?
Does a high sodium diet increase blood pressure and cardiac hypertrophy in Wistar rats?
A high sodium diet induces hypertension and cardiac hypertrophy in rats, which is associated with compensatory increases in AT1 receptor expression and p38MAPK abundance.
High-sodium diet effects in rats support mechanistic hypotheses; leaves open translation to human hypertension management.
BACKGROUND: Sodium-induced hypertensive cardiac hypertrophy is related to pressure and volume overload. METHODS: Wistar rats were exposed to low and high sodium diet for 8 weeks. Angiotensin II receptor mRNA, abundance of p38 mitogen-activated protein kinase (p38MAPK), vasoconstriction of aortic rings, and angiotensin II-induced calcium increase were investigated. RESULTS: Rats on high sodium diet showed significantly elevated blood pressure. Heart weight, AT1 receptor mRNA in cardiac and aortic tissues, and abundance of p38MAPK were significantly increased in rats on high sodium diet. CONCLUSIONS: Increased AT1 receptor expression and angiotensin II-induced calcium increase are compensatory effects in sodium-induced hypertension.
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Zhiming Zhu (2003) studied this question.
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