Measurement of Parameters Characterizing Early Vascular Aging with the Use of an Oscillometric Method during Spaceflight

The article is devoted to the study of the state of the vascular wall based on the data on pulse wave velocity used as a vascular biomarker to predict and prevent early vascular aging. The studies were carried out on Russian cosmonauts who performed 6-month space flights using a Mobilograph device, which passed all the necessary tests, was certified for operation on board the International Space Station and allows evaluating the parameters of central hemodynamics. The experiment was carried out twice before the flight, every month during the flight, and also on days +4 and +8 after landing. Pulse wave velocity in all measurements was not shown to exceed the threshold values, thus suggesting the absence of vascular risk and the risk of cardiovascular pathologies in astronauts working in low-Earth orbit. However, this conclusion may be limited by the features of the method and the device used.