Why the study?
Does early versus delayed lisinopril treatment improve survival and cardiac remodeling in a rat model of heart failure post-myocardial infarction?
Population
Rat model of congestive heart failure after myocardial infarction
Comparison
Lisinopril 10 mg/kg/day initiated early or late vs Placebo
Design
Preclinical
Follow-up
9 months
Authors
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Supports ACE inhibition timing in post-MI rat models; leaves open translation to human trials.
Does early versus delayed lisinopril treatment improve survival and cardiac remodeling in a rat model of heart failure post-myocardial infarction?
In a rat model of post-MI heart failure, both early and delayed ACE inhibition with lisinopril improved survival and reversed cardiac remodeling.
Mulder et al. (1997) studied this question.
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