Why the study?
Are noninvasive measures of vascular function associated with new-onset atrial fibrillation in adults aged ≥45 years?
Population
5,797 participants aged ≥45 years from the Framingham Heart Study offspring and third-generation cohorts.
Design
Cohort
Follow-up
median 7.1 years, maximum 10 years
Authors
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Lower FMD and larger brachial diameter associated with incident AF; leaves open whether vascular measures improve risk stratification or prevention.
Are noninvasive measures of vascular function associated with new-onset atrial fibrillation in adults aged ≥45 years?
Vascular endothelial dysfunction, higher pulsatile load, and greater apparent wave reflection are associated with an increased risk of incident atrial fibrillation, suggesting vascular changes may precede AF development.
Shaikh et al. (2016) studied this question.
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