Why the study?
Do intravenous E-4031 and MS-551 alter electrophysiologic parameters in patients with ventricular tachyarrhythmias?
Do intravenous E-4031 and MS-551 alter electrophysiologic parameters in patients with ventricular tachyarrhythmias?
Intravenous E-4031 and MS-551 prolong repolarization and refractoriness in a reverse use-dependent manner in patients with ventricular tachyarrhythmias.
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Caution against use in ventricular tachyarrhythmias; case report leaves clinical benefit and safety open for randomized trials.
Naitoh et al. (1998) studied this question.
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