Why the study?
Does human AKT1 gene transfer improve endothelial vasorelaxation and blood flow in spontaneously hypertensive rats?
Population
Normotensive Wistar-Kyoto rats, spontaneously hypertensive rats, and primary cultured endothelial cells
Comparison
Adenoviral vectors to transfer the human AKT1… vs Control carotids from SHR and WKY rats without…
Design
Preclinical
Authors
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AKT1 modulation merits further preclinical study in hypertension; leaves open any human therapeutic role.
Does human AKT1 gene transfer improve endothelial vasorelaxation and blood flow in spontaneously hypertensive rats?
AKT1 gene transfer corrects endothelial dysfunction and normalizes blood flow in spontaneously hypertensive rats, suggesting AKT mislocalization contributes to hypertensive endothelial dysfunction.
Iaccarino et al. (2004) studied this question.
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