Formulation and Evaluation of β-Cyclodextrin Grafted Chitosan Nanocomposites for Controlled release of Anticancer Drug Cyclophosphamide

In this paper β -cyclodextrin (β-CD) grafted chitosan (CS) with MMT was different feed ratio known as (β-CD-gCS/MMT). The prepared nanocomposites were characterized by XRD, FTIR, SEM, TGA, TDC and swelling in stimulated in different biological fluid. The model drug Cyclophosmide (CYC) was used for controlled drug delivery purpose. From FTIR result was clearly demonstrated that the model drug CYC did not change in any molecular level at β-CD-g-CS/MMT (i.e. at less than 10 nm scale). Additionally, in DSC result, CYC was interacted with nanocomposites at scale >100 nm level. In vitro drug release system was carried out by Korsmeyer Peppas’s power law. CYC and other drugs like Doxorubicin (DOX) and Curcumin (CUM) were presented exceptional higher drug result in different pH medium. It was observed that CS/MMT was decrease less drug release rate compared to β-CD-g-CS/MMT. So that it can be clearly understood that β-CD-gCS/MMT grafted nanocomposites have enhanced drug release activity in different pH medium.