Peripheral Flow Response to Transient Arterial Forearm Occlusion Does Not Reflect Myocardial Perfusion Reserve
Why the study?
Does peripheral flow response to transient forearm ischemia correlate with dipyridamole-induced myocardial hyperemia in patients with CAD, syndrome X, and healthy controls?
Population
84 subjects, including 23 patients with documented coronary artery disease, 16 patients with syndrome X, and…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Peripheral assessment does not support surrogates for myocardial perfusion; leaves open whether microcirculatory beds are independently regulated.
Structured PICO
Does peripheral flow response to transient forearm ischemia correlate with dipyridamole-induced myocardial hyperemia in patients with CAD, syndrome X, and healthy controls?
P
Population
84 subjects, including 23 patients with documented coronary artery disease (CAD; 66+/-9 years old, 18 men), 16 patients with syndrome X (SX; 56+/-5 years old, 13 women), and 45 healthy control subjects (C; 34+/-9 years old, 22 men).
I
Intervention
Measurement of myocardial perfusion by PET (at rest and after dipyridamole 0.56 mg/kg/min over 4 minutes) and brachial artery blood flow by Doppler ultrasound (at rest and after transient forearm ischemia).
O
Outcome
Correlation between peripheral and myocardial microcirculatory beds for resting flow, hyperemic flow, and flow reserve.surrogate
Peripheral perfusion responses to transient forearm ischemia do not correlate with dipyridamole-induced myocardial hyperemia, indicating that systemic microcirculation assessment cannot be used as a surrogate marker for myocardial perfusion.
Cite This Study
Bøttcher et al. (2001) studied this question.