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August 10, 2017PLoS ONEOpen Access

Improved early risk stratification of patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention using a combination of serum soluble ST2 and NT-proBNP

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Why the study?

Do elevated serum sST2 and NT-proBNP levels at presentation predict 1-year MACCE in STEMI patients undergoing primary PCI?

Population

323 consecutive patients with STEMI undergoing primary PCI, mean age 59.1±13.1 years, 84% men.

Comparison

High serum sST2 and/or high serum NT-proBNP at… vs Low serum sST2 and/or low serum NT-proBNP at…

Design

Cohort

Follow-up

1 year

Authors

JYJongwook YuYonsei UniversityPOPyung Chun OhGachon UniversityMKMinsu KimSeoul National University

Discussion

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Implication

Serum sST2 may refine post-PCI STEMI risk stratification; leaves open whether it improves outcomes over standard markers in prospective trials.

Structured PICO

Do elevated serum sST2 and NT-proBNP levels at presentation predict 1-year MACCE in STEMI patients undergoing primary PCI?

P
Population
323 consecutive patients with STEMI undergoing primary PCI, mean age 59.1±13.1 years, 84% men.
I
Intervention
High serum sST2 (>75.8 ng/mL) and/or high serum NT-proBNP (>400 pg/mL) at presentation
C
Comparator
Low serum sST2 and/or low serum NT-proBNP at presentation
O
Outcome
1-year major adverse cardiovascular and cerebrovascular events (MACCEs), defined as a composite of cardiovascular death, non-fatal MI, non-fatal stroke, and ischemia-driven revascularizationcomposite

Elevated serum sST2 and NT-proBNP at presentation independently predict 1-year MACCE in STEMI patients undergoing primary PCI, with the combination yielding the highest risk.

Cite This Study

Yu et al. (2017) studied this question.

synapsesocial.com/papers/6a72da3c5d37378ac1df725ehttps://doi.org/10.1371/journal.pone.0182829

Topics

STEMI managementPercutaneous coronary intervention
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