The contribution of KCa and KV7 channels to coronary vasodilator responses is markedly impaired in the setting of obesity, altering how perivascular adipose tissue influences coronary vasodilation.
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Obesity impairs KCa/KV7-mediated coronary vasodilation in animal arteries; hypothesis-generating for altered PVAT effects in human disease.
Noblet et al. (2014) studied this question.
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