Population
Isolated coronary arteries from lean and obese Ossabaw swine
Comparison
Exposure to factors derived from lean and obese… vs Arteries in the absence of PVAT; lean versus…
Design
Preclinical
Authors
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Should not yet inform clinical practice; leaves open differential PVAT-K+ channel effects as obesity-specific coronary vasomotor mechanisms.
Lean and obese coronary PVAT impair vasodilation through differential inhibition of vascular smooth muscle K+ channels, highlighting a potential mechanism for smooth muscle dysfunction in obesity.
Noblet et al. (2015) studied this question.
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