Why the study?
Does glucose pretreatment block the increase in stroke volume and cardiac output produced by smoking in healthy habitual smokers?
Does glucose pretreatment block the increase in stroke volume and cardiac output produced by smoking in healthy habitual smokers?
Glucose pretreatment blocks the smoking-induced increase in stroke volume and diminishes the cardiac output response in healthy smokers.
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Glucose may blunt acute hemodynamic responses to smoking; leaves open clinical relevance and requires confirmation in larger studies.
The percentage changes in the cardiac output, stroke volume, and heart rate were determined in seven healthy habitual smokers after smoking, after glucose, and after smoking preceded by glucose. No significant changes occur after glucose. There is a significant increase in cardiac output, stroke volume, and heart rate after smoking. Pretreatment with glucose did not change the heart-rate response to smoking. Nevertheless, the cardiac-output response was diminished. This decrease is due to a block in the increase in stroke volume induced by smoking.
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Moses et al. (1964) studied this question.
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