Population
Vascular endothelial and smooth muscle cells
Comparison
Perturbation or injury vs Normal unperturbed state
Design
Review
Authors
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Vascular injury may promote thrombosis via cell phenotype shift; leaves open targeted antithrombotic strategies pending clinical validation.
Vascular endothelial and smooth muscle cells shift from an antithrombotic to a thrombogenic state upon injury, providing a mechanistic basis for thrombosis and vascular disease.
George M. Rodgers (1988) studied this question.
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