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Evaluate the chemical and genetic diversity of Polygoni Multiflori Caulis and assess the authenticity of commercial products.

August 5, 2026PeerJOpen Access

Integrated chemical and genetic authentication of Polygoni Multiflori Caulis: Refuting diameter restrictions and exposing market adulteration

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Randomized trial evaluates chemical and genetic authenticity of PMC, revealing market substitutions and diameter standards.

Evaluate the chemical and genetic diversity of Polygoni Multiflori Caulis and assess the authenticity of commercial products.
Analyzed authenticated samples of PM, PMH, and PA using high-performance liquid chromatography for key markers.
Sequenced the ITS2 region to evaluate genetic diversity and identify single nucleotide polymorphisms (SNPs).
Surveyed eleven commercial PMC samples from Taiwanese markets.
PMC samples across 2.0 to 25.1 mm meet Taiwan Herbal Pharmacopoeia standards, challenging 4-7 mm diameter limits.
Authenticated PMH samples lack THSG, while PA exhibit variable chemical phenotypes; only a subset meets standards.
82% of commercial samples were substituted with PA, with 72% showing undetectable required analytes.

Ngo et al. (2026) studied this question.

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