What question did this study set out to answer?

This research aims to investigate the relationship between diabetic control and the progression of monoclonal gammopathy of undetermined significance to multiple myeloma.

August 5, 2026Blood Cancer JournalOpen Access

Association between diabetic control and progression of monoclonal gammopathy of undetermined significance to multiple myeloma

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This research aims to investigate the relationship between diabetic control and the progression of monoclonal gammopathy of undetermined significance to multiple myeloma.
Conducted a retrospective cohort study of US Veterans diagnosed with MGUS from 1999 to 2023 with prior diabetes mellitus.
Utilized multivariable-adjusted hazard ratio estimated by the Fine-Gray subdistribution hazard model.
Analyzed the impact of time-varying glycated hemoglobin (HbA1c) on the progression to multiple myeloma.
Among 11,061 patients with diabetes mellitus, HbA1c > 7% was associated with increased progression risk (aHR 1.15; 95% CI 1.01–1.32).
In type-2 diabetes patients using insulin (n=7070), the aHR was 1.46 (95% CI 1.19–1.78).
For non-insulin users (n=3724), the aHR was 1.42 (95% CI 1.14–1.77).

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Implication

Retrospective cohort study finds that poorly controlled diabetes increases the risk of progression to multiple myeloma in veterans with MGUS, implying a need for better diabetes management.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a72e86e226790f370658574 https://doi.org/10.1038/s41408-026-01592-x

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Implication

Retrospective cohort study finds that poorly controlled diabetes increases the risk of progression to multiple myeloma in veterans with MGUS, implying a need for better diabetes management.

Association between diabetic control and progression of monoclonal gammopathy of undetermined significance to multiple myeloma

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Discussion

Implication

Cite This Study

Association between diabetic control and progression of monoclonal gammopathy of undetermined significance to multiple myeloma

Key Points

Discussion

Implication

Cite This Study

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