Why the study?
Does anticoagulant therapy reduce reinfarction and death in patients with acute myocardial infarction?
Does anticoagulant therapy reduce reinfarction and death in patients with acute myocardial infarction?
Anticoagulant therapy is recommended for 1 to 2 years following acute myocardial infarction to reduce the risk of reinfarction and death.
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May support extended post-MI anticoagulation; leaves open relevance with modern reperfusion and antiplatelet strategies.
In summary, the total world evidence suggests that in the absence of compelling contraindications and with the availability of satisfactory laboratory and clinical facilities, patients suffering with acute myocardial infarction should receive adequate anticoagulant therapy during the first month, and that the risk of reinfarction and death is reduced if this is continued for 1 to 2 years after the first month. More long-term studies should be conducted to evaluate this treatment for succeeding years. This form of therapy presents certain difficulties that must be weighed against the possible gains in deciding whether or not to continue it.
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Irving S. Wright (1964) studied this question.
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