What question did this study set out to answer?

To determine the prognostic significance of left ventricular concentric remodeling in patients with essential hypertension and normal left ventricular mass.

April 1, 1995American Journal of Hypertension

Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive subjects with normal left ventricular mass.

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Why the study?

Does concentric remodeling of the left ventricle predict major cardiovascular morbid events in hypertensive subjects with normal left ventricular mass?

Population

694 subjects with essential hypertension and normal left ventricular mass at echocardiography

Comparison

Concentric remodeling of the left ventricle vs Normal left ventricular geometry

Design

Cohort

Follow-up

up to 7.7 years (mean 2.71 years)

Authors

PVP. VerdecchiaEuropean Society of Hypertension

Discussion

Member takes

Implication

May identify higher-risk hypertensives despite normal mass; leaves open whether geometry should guide therapy.

Key Points

To determine the prognostic significance of left ventricular concentric remodeling in patients with essential hypertension and normal left ventricular mass.
Prospective evaluation of 694 hypertensive subjects with normal left ventricular (LV) mass (<125 g/m²) followed for up to 7.7 years (mean: 2.71 years).
Baseline evaluations included echocardiography and 24-hour ambulatory blood pressure monitoring, defining concentric remodeling as a relative wall thickness ≥ 0.45.
Concentric remodeling was present in 39.2% of patients, with cardiovascular event rates of 2.39 per 100 patient-years versus 1.12 per 100 patient-years in those with normal geometry across 29 total events.
Multivariable Cox regression revealed a significantly higher risk of cardiovascular morbid events in patients with concentric remodeling compared to normal geometry (RR: 2.56; 95% CI: 1.20 to 5.45; p < 0.01).

Structured PICO

Does concentric remodeling of the left ventricle predict major cardiovascular morbid events in hypertensive subjects with normal left ventricular mass?

Population

694 subjects with essential hypertension and normal left ventricular (LV) mass at echocardiography (< 125 g/m2)

Intervention

Concentric remodeling of the left ventricle (thickness of septum or posterior wall divided by LV radius at telediastole ≥ 0.45)

Comparator

Normal left ventricular geometry

Outcome

Major cardiovascular morbid events (fatal and nonfatal)hard clinical

Concentric remodeling of the left ventricle is an independent predictor of increased cardiovascular risk in hypertensive patients even when left ventricular mass is normal.

Cite This Study

P. Verdecchia (1995) studied this question.

synapsesocial.com/papers/6a72ea93256db8d1b21cf32e https://doi.org/10.1016/0895-7061(95)97990-9

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Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive subjects with normal left ventricular mass.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Adverse prognostic significance of concentric remodeling of the left ventricle in hypertensive subjects with normal left ventricular mass.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider