Postprandial plasma retinyl ester response is greater in older subjects compared with younger subjects. Evidence for delayed plasma clearance of intestinal lipoproteins.

View Full Paper

Ask AI

Bookmark

Why the study?

Does advancing age delay the plasma clearance of intestinal lipoproteins (measured via retinyl esters) in healthy adults?

Structured PICO

Does advancing age delay the plasma clearance of intestinal lipoproteins (measured via retinyl esters) in healthy adults?

Population

86 healthy men and women, aged 19-76 yr

Intervention

Vitamin A supplementation (oral dose of 3,000 RE without meal, 20 RE/kg with fat-rich meal, or intravenous infusion of retinyl ester-rich plasma)

Comparator

Younger subjects (aged <50 yr or 18-30 yr) vs. older subjects (aged >=50 yr or >=60 yr)

Outcome

Postprandial plasma retinyl ester response and rate of retinyl ester disappearance from plasmasurrogate

Older age is associated with delayed plasma clearance of retinyl esters in triglyceride-rich lipoproteins of intestinal origin.

No takes yet. Share an insight, caveat, or question.

May delay postprandial lipemia in older adults; hypothesis-generating and requires prospective validation before clinical consideration.

Krasinski et al. (1990) studied this question.

View Full Paper

Ask AI

Bookmark