Why the study?
Does harmaline affect the action potential amplitude in rat atrial fibres?
Does harmaline affect the action potential amplitude in rat atrial fibres?
Harmaline transiently enhances the action potential amplitude in rat atrial fibers via beta-adrenergic stimulation of the slow component.
Harmaline effects on rat atrial fibers warrant no clinical changes; leaves open translation of beta-adrenergic modulation to human electrophysiology.
The mechanism of the transient enhancement of the amplitude of the action potential (AAP) induced by harmaline (HME) was studied in rat atria. The results show that HME increases AAP through an enhancement of the slow component responsible for the last part of the upstroke, which overcomes an inhibitory action on the initial fast component. The stimulatory effect on the slow component is mediated through adrenergic beta receptors and normally masks an alpha-dependent depressant effect.
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Carpentier et al. (1977) studied this question.
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