Key result
Inherited mutations in nitric oxide signaling genes are linked to premature atherothrombotic disease.
Population
A family with excessive cardiovascular disease in younger adults
Answers are grounded in this paper and cite their sources.
No immediate clinical application for these mutations; leaves open their role in broader atherothrombotic disease.
A recent article in Nature by Erdmann et al studies a family with excessive cardiovascular disease in younger adults and identifies mutations in 2 functionally related genes that may be linked to atherothrombotic disease.
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Jane E. Freedman (2014) studied this question. Inherited mutations in 2 functionally related genes involved in nitric oxide signaling may be linked to atherothrombotic disease in younger adults.
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