Population
Whole platelets and platelet mixed membrane fractions
Comparison
[acetyl-14C]aspirin vs Aromatic-ring-labelled [14C]aspirin
Design
Preclinical
Authors
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Animal platelet data on aspirin acetylation; leaves open human confirmation and does not support practice changes.
Aspirin inhibits platelet cyclo-oxygenase by acetylating a 72kDa polypeptide located in the intracellular membranes (dense tubular membrane system).
Hack et al. (1984) studied this question.
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