November 1, 1980British Journal of Haematology
Impaired Thromboxane Production by Newly Formed Platelets after Aspirin Administration to Thrombocytopenic Rats
Why the study?
Does aspirin inhibit megakaryocyte cyclo-oxygenase in thrombocytopenic rats?
Population
Rats made thrombocytopenic by a specific antiplatelet antiserum 2 hours after treatment administration
Comparison
Aspirin 100 mg/kg administered intraperitoneally vs Saline administered intraperitoneally (i.p.)
Design
Preclinical
Follow-up
96 hours
Authors
Discussion
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Member takes
Implication
Supports megakaryocyte COX inhibition by aspirin in rats; leaves open human translation in thrombocytopenia.
Structured PICO
Does aspirin inhibit megakaryocyte cyclo-oxygenase in thrombocytopenic rats?
P
Population
Rats made thrombocytopenic (platelet count less than 5% of basal value) by a specific antiplatelet antiserum 2 hours after treatment administration
I
Intervention
Aspirin 100 mg/kg administered intraperitoneally (i.p.)
C
Comparator
Saline administered intraperitoneally (i.p.)
O
Outcome
Malondialdehyde (MDA) and thromboxane B2 (TxB2) production by platelets during the period of platelet count restoration (measured at 24 and 96 hours)surrogate
Aspirin significantly delays the recovery of platelet cyclo-oxygenase activity in thrombocytopenic rats, supporting the hypothesis that the drug also inhibits megakaryocyte cyclo-oxygenase.
Cite This Study
Dejana et al. (1980) studied this question.