Key result
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells formed tumors resembling human myxoid liposarcoma in mice, whereas EWS-ATF1 and SYT-SSX1 failed to transform them.
Population
Primary mesenchymal progenitor cells (MPCs) and in vivo mouse model
Comparison
Expression of sarcoma-associated fusion proteins… vs MPCs expressing EWS-ATF1, SYT-SSX1, or…
Design
Preclinical
Authors
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FUS-CHOP may initiate myxoid liposarcoma in vivo; leaves open therapeutic targeting in patients.
Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells is sufficient to initiate myxoid liposarcoma pathogenesis in vivo.
Riggi et al. (2006) studied Myxoid liposarcoma. Expression of FUS-CHOP fusion protein in primary mesenchymal progenitor cells vs. Expression of EWS-ATF1 and SYT-SSX1 was evaluated on Tumorigenic potential in vivo. Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells formed tumors resembling human myxoid liposarcoma in mice, whereas EWS-ATF1 and SYT-SSX1 failed to transform them.
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