Key result
In patients with nonischemic ventricular arrhythmias, MRI late gadolinium enhancement demonstrated 74% sensitivity and 46.9% specificity for diagnosing myocarditis compared to endomyocardial biopsy.
Why the study?
Does endomyocardial biopsy and MRI improve the diagnostic evaluation of inflammatory myocardial disease in patients with nonischemic ventricular arrhythmias?
Observational (n=100)
No
Does endomyocardial biopsy and MRI improve the diagnostic evaluation of inflammatory myocardial disease in patients with nonischemic ventricular arrhythmias?
Endomyocardial biopsy is valuable for identifying inflammatory etiologies in nonischemic ventricular arrhythmias, as MRI has limited diagnostic accuracy for myocarditis and postinflammatory fibrosis.
Endomyocardial biopsy remains key for myocarditis in nonischemic arrhythmias; leaves open optimal MRI integration pending prospective validation.
Objective. To study the etiology of nonischemic ventricular arrhythmias and to improve diagnostic evaluation of inlammatory myocardial disease using endomyocardial biopsy. Design and methods. We performed 100 endomyocardial biopsies during catheter ablation in patients with nonischemic ventricular arrythmias. Results. Myocarditis was veriied in 58 cases, and postinlammatory ibrosis — in 24 cases. Twenty three patients (67 %) demonstrated active myocarditis, 1 (2,9 %) had chronic active myocarditis, and 10 subjects (29 %) — chronic non-active myocarditis. Conclusion. Endomyocardial biopsy contributes to better veriication of the etiology of ventricular arrhythmias. Late gadolinium enhancement during magnetic resonance imaging shows 74 % sensitivity and 46,9 % speciicity in the evaluation of myocarditis, and 52,4 % sensitivity and 38,9 % speciicity in veriication of postinlammatory ibrosis. Presence of CD-8+ cells, Ig M, patchy dystrophin expression can be additional features for veriication of active myocarditis.
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Лебедев et al. (2013) conducted an observational in Nonischemic ventricular arrhythmias (n=100). Magnetic Resonance Imaging (MRI) and Endomyocardial Biopsy was evaluated on Diagnostic sensitivity and specificity of MRI late gadolinium enhancement for myocarditis. In patients with nonischemic ventricular arrhythmias, MRI late gadolinium enhancement demonstrated 74% sensitivity and 46.9% specificity for diagnosing myocarditis compared to endomyocardial biopsy.
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