Why the study?
Does oral propranolol prevent the pressor response to exercise in a patient with coarctation of the aorta?
Does oral propranolol prevent the pressor response to exercise in a patient with coarctation of the aorta?
Propranolol may minimize dangerous blood pressure elevations during exercise in patients with coarctation of the aorta.
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May blunt exercise BP rise in coarctation; hypothesis-generating and should not change practice.
In a patient with coarctation of the aorta, blood pressure and heart rate were measured during graded exercise on a bicycle ergometer. After no treatment, and after oral hydrallazine, exercise produced large rises in systolic and diastolic blood pressures, and in heart rate. During exercise after oral propranolol, systolic and diastolic pressures did not increase, and there was a less marked tachycardia. These results suggest that propranolol should be used to minimize the dangers of elevated blood pressure associated with exercise in patients with coarctation.
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Rampton et al. (1977) studied this question.
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