Key result
Combined administration of nicorandil and atorvastatin significantly improved overall treatment effectiveness (94% vs 54%) compared to nicorandil alone in patients with acute myocardial infarction after coronary intervention.
Why the study?
The study investigated the effect of combined nicorandil and atorvastatin calcium on postoperative cardiac systolic function in patients with acute myocardial infarction following coronary intervention.
Does the combined administration of nicorandil and atorvastatin improve postoperative cardiac systolic function and clinical outcomes in patients with acute myocardial infarction after coronary intervention?
Population
100 patients with acute myocardial infarction treated with coronary interventional therapy
Comparison
Nicorandil plus atorvastatin vs nicorandil alone
Design
Retrospective randomised study
Authors
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Suggests possible benefit of adding atorvastatin to nicorandil post-PCI in AMI; hypothesis-generating and requires randomized confirmation before practice change.
RCT (n=100)
Randomized
No
Does the combined administration of nicorandil and atorvastatin improve postoperative cardiac systolic function and clinical outcomes in patients with acute myocardial infarction after coronary intervention?
Absolute Event Rate: 94% vs 54%
p-value: p=< 0.001
The combination of nicorandil and atorvastatin significantly improves cardiac systolic function, lipid profiles, and overall treatment effectiveness in patients with acute myocardial infarction following percutaneous coronary intervention.
Sun et al. (2021) conducted an RCT in Acute myocardial infarction after percutaneous coronary intervention (n=100). Nicorandil and atorvastatin vs. Nicorandil 5 mg t.i.d. was evaluated on Treatment effectiveness (p=< 0.001). Combined administration of nicorandil and atorvastatin significantly improved overall treatment effectiveness (94% vs 54%) compared to nicorandil alone in patients with acute myocardial infarction after coronary intervention.
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