Key result
Recurrent atrial fibrillation after catheter ablation was independently associated with a higher risk of worsening renal function (HR 1.89), which strongly predicted adverse clinical outcomes.
Why the study?
Atrial fibrillation and renal failure coexist and interact, but data on the association between renal function and clinical outcomes after catheter ablation for AF were scarce.
Does atrial fibrillation recurrence after catheter ablation increase the risk of worsening renal function and subsequent adverse clinical outcomes in non-dialysis patients?
Cohort (n=791)
No
Does atrial fibrillation recurrence after catheter ablation increase the risk of worsening renal function and subsequent adverse clinical outcomes in non-dialysis patients?
Hazard Ratio: 1.89 (95% CI 1.27–2.81)
Absolute Event Rate: 21.6% vs 8.7%
p-value: p=0.002
Arrhythmia recurrence after atrial fibrillation ablation is associated with worsening renal function, which strongly predicts subsequent mortality and heart failure hospitalization.
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May warrant closer renal monitoring after ablation failure; leaves open whether successful rhythm control preserves kidney function.
Kawaji et al. (2020) conducted a cohort in Atrial fibrillation (n=791). Recurrent atrial fibrillation vs. Maintained sinus rhythm was evaluated on Worsening renal function (WRF) defined as >30% decline in estimated glomerular filtration rate (HR 1.89, 95% CI 1.27-2.81, p=0.002). Recurrent atrial fibrillation after catheter ablation was independently associated with a higher risk of worsening renal function (HR 1.89), which strongly predicted adverse clinical outcomes.
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