Key result
A derived multiparametric score correlated with LV volume reduction after CRT (r = -0.5, P < 0.001), with a score <0.6 offering 100% positive predictive value for non-response.
Why the study?
Does a multiparametric score incorporating dyssynchrony, LV function, and LV lead position predict left ventricular remodelling and prognosis in patients undergoing cardiac resynchronization therapy?
Cohort (n=294)
No
Does a multiparametric score incorporating dyssynchrony, LV function, and LV lead position predict left ventricular remodelling and prognosis in patients undergoing cardiac resynchronization therapy?
Effect estimate: r = -0.5
p-value: p=< 0.001
A novel multiparametric score incorporating echocardiographic parameters and LV lead position can accurately predict non-response to CRT, potentially helping to avoid unnecessary device implantations.
No takes yet. Share an insight, caveat, or question.
May aid pre-CRT non-response identification; leaves open prospective validation before guiding selection.
Kydd et al. (2014) conducted a cohort in Heart failure requiring Cardiac Resynchronization Therapy (n=294). Multiparametric predictive score was evaluated on Response (≥15% reduction in LV end-systolic volume) (r = -0.5, p=< 0.001). A derived multiparametric score correlated with LV volume reduction after CRT (r = -0.5, P < 0.001), with a score <0.6 offering 100% positive predictive value for non-response.
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